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![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_660c0342d623e.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_613906d8c2d75.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_65faf705a8a1b.jpg)
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![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_6368c1e2e4402.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_65eec3665fcfa.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_6669b9181a063.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_659eabb02128f.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_659eaaddd8a7d.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_66017c606cbc1.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_6405f9a80b28b.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_65fb12fc3d298.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_65535714a9509.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_635fa0dd909f0.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_5abb84e4aee13.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_65953045e21f7.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_641182e4a28ca.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_6411a53eb8e5d.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_660c0bf27876a.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_657ab0134b5bf.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_64de0736433e1.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_6409fe87cbccf.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_638f3329ebd3d.jpg)
![What exactly is amyloidosis?](https://media-manager.starsinsider.com/gallery/1080/na_660c0e2567e6f.jpg)
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See Also
See Again
© Shutterstock
0 / 31 Fotos
Introducing amyloidosis
- Amyloidosis is a rare but potentially serious disease in which a protein called amyloid builds up in the organs, causing them to malfunction.
© Shutterstock
1 / 31 Fotos
Affected organs
- Several organs can be affected by amyloidosis, including the heart, kidneys, liver, spleen, nervous system, and digestive tract.
© Shutterstock
2 / 31 Fotos
With other diseases
- In some cases, amyloidosis occurs with other diseases, such as rheumatoid arthritis. In these cases, amyloidosis symptoms may improve with treatment for the other disease.
© Shutterstock
3 / 31 Fotos
On its own
- In other cases, amyloidosis occurs on its own. Treatment often includes chemotherapy, as well as other strong drugs that are used to treat cancer.
© iStock
4 / 31 Fotos
Onset of symptoms
- The symptoms of amyloidosis do not usually present until the later stages of the disease, and they tend to vary depending on which organs are affected.
© Shutterstock
5 / 31 Fotos
Symptoms
- Symptoms can include severe fatigue, shortness of breath, swelling of the ankles and legs, and numbness, pain, or tingling in the hands or feet.
© Shutterstock
6 / 31 Fotos
Further symptoms
- Further symptoms include diarrhea or constipation, an enlarged tongue that can look rippled around the edges, and skin changes such as easy bruising.
© Shutterstock
7 / 31 Fotos
Seeking medical attention
- It is important to seek medical attention if you experience, or someone you know regularly experiences, any of the symptoms associated with amyloidosis.
© Shutterstock
8 / 31 Fotos
Causes
- There are several different types of amyloidosis. Some of the variations are hereditary, while others may be caused by an inflammatory disease.
© Shutterstock
9 / 31 Fotos
Primary amyloidosis
- The most common type of amyloidosis in developed countries is AL amyloidosis. Also referred to as ‘primary amyloidosis,’ this variation usually affects the heart, kidneys, liver, and nerves.
© Shutterstock
10 / 31 Fotos
Secondary amyloidosis
- Next up is AA amyloidosis, also known as ‘secondary amyloidosis.’ This is usually triggered by an inflammatory disease and primarily affects the kidneys, liver, and spleen.
© Shutterstock
11 / 31 Fotos
Hereditary amyloidosis
- Hereditary amyloidosis, or familial amyloidosis, is an inherited disorder that occurs when a protein made by the liver is abnormal. It mainly affects the nerves, heart, and kidneys.
© Shutterstock
12 / 31 Fotos
Wild-type amyloidosis
- Wild-type amyloidosis occurs when the same liver protein is normal, but it still produces amyloid for unknown reasons. It is most common in men over 70 and tends to affect the heart.
© Shutterstock
13 / 31 Fotos
Localized amyloidosis
- Finally, we have localized amyloidosis, which affects a single site only. Common parts of the body affected by localized amyloidosis include the bladder, skin, throat, and lungs.
© Shutterstock
14 / 31 Fotos
Diagnosing localized amyloidosis
- With localized amyloidosis, it is very important to get the diagnosis right so that general treatments which affect the whole body can be avoided.
© iStock
15 / 31 Fotos
Risk factors
- In terms of risk factors, age and sex are both important. Amyloidosis is normally diagnosed in people between the ages of 60 and 70, and it is more common in men.
© Shutterstock
16 / 31 Fotos
Race
- Race may also play a role: people of African descent appear to be more likely to carry the genetic mutation associated with a type of amyloidosis that harms the heart.
© Shutterstock
17 / 31 Fotos
Kidney dialysis
- In some cases, kidney dialysis can put people at a higher risk of amyloidosis, since it can cause proteins to build up in the blood and eventually be deposited in tissue.
© Shutterstock
18 / 31 Fotos
Kidney dialysis
- However, amyloidosis caused by complications with kidney dialysis is less common nowadays thanks to modern dialysis techniques.
© Shutterstock
19 / 31 Fotos
Diagnosis
- Amyloidosis can be difficult to diagnose because some of the symptoms are very general and can mimic the symptoms of other, more common diseases.
© Shutterstock
20 / 31 Fotos
Early and precise
- That said, early diagnosis is important, since it can help to prevent further organ damage. Precise diagnosis is also important since treatment varies depending on the condition.
© Shutterstock
21 / 31 Fotos
Blood & urine tests
- If your doctor or healthcare professional suspects amyloidosis, they may order blood and/or urine tests to check for an abnormal protein that indicates the disease.
© Shutterstock
22 / 31 Fotos
Tissue samples
- They may also order a tissue sample, otherwise known as a biopsy, to check for signs of amyloidosis.
© Shutterstock
23 / 31 Fotos
Imaging tests
- Imaging tests, such as echocardiograms, MRIs, and nuclear imaging tests can also be used to check the organs for signs of amyloidosis.
© Shutterstock
24 / 31 Fotos
Treatment
- There is no cure for amyloidosis. Instead, treatment focuses on managing the symptoms and limiting any further production of the amyloid protein.
© Shutterstock
25 / 31 Fotos
Chemotherapy
- In the case of AL amyloidosis, chemotherapy is often used to stop the growth of the abnormal cells that produce the protein that produces amyloid.
© Shutterstock
26 / 31 Fotos
Blood thinners
- In cases of amyloidosis that affects the heart, patients may need to take blood thinners to reduce the risk of throwing a blood clot.
© Shutterstock
27 / 31 Fotos
Other medications
- They may also need to take medications to control heart rate, as well as drugs that increase urination, so as to reduce the strain on the heart and kidneys.
© Shutterstock
28 / 31 Fotos
Surgery
- There are also targeted therapies for specific types of amyloidosis, as well as surgical procedures that may be ordered as part of treatment.
© Shutterstock
29 / 31 Fotos
In conclusion
- Living with this rare disease can be difficult, but early diagnosis and the right treatment can help to manage symptoms and prevent complications. Sources: (Mayo Clinic) (NHS) See also: The rare inflammatory condition that is sarcoidosis
© Shutterstock
30 / 31 Fotos
© Shutterstock
0 / 31 Fotos
Introducing amyloidosis
- Amyloidosis is a rare but potentially serious disease in which a protein called amyloid builds up in the organs, causing them to malfunction.
© Shutterstock
1 / 31 Fotos
Affected organs
- Several organs can be affected by amyloidosis, including the heart, kidneys, liver, spleen, nervous system, and digestive tract.
© Shutterstock
2 / 31 Fotos
With other diseases
- In some cases, amyloidosis occurs with other diseases, such as rheumatoid arthritis. In these cases, amyloidosis symptoms may improve with treatment for the other disease.
© Shutterstock
3 / 31 Fotos
On its own
- In other cases, amyloidosis occurs on its own. Treatment often includes chemotherapy, as well as other strong drugs that are used to treat cancer.
© iStock
4 / 31 Fotos
Onset of symptoms
- The symptoms of amyloidosis do not usually present until the later stages of the disease, and they tend to vary depending on which organs are affected.
© Shutterstock
5 / 31 Fotos
Symptoms
- Symptoms can include severe fatigue, shortness of breath, swelling of the ankles and legs, and numbness, pain, or tingling in the hands or feet.
© Shutterstock
6 / 31 Fotos
Further symptoms
- Further symptoms include diarrhea or constipation, an enlarged tongue that can look rippled around the edges, and skin changes such as easy bruising.
© Shutterstock
7 / 31 Fotos
Seeking medical attention
- It is important to seek medical attention if you experience, or someone you know regularly experiences, any of the symptoms associated with amyloidosis.
© Shutterstock
8 / 31 Fotos
Causes
- There are several different types of amyloidosis. Some of the variations are hereditary, while others may be caused by an inflammatory disease.
© Shutterstock
9 / 31 Fotos
Primary amyloidosis
- The most common type of amyloidosis in developed countries is AL amyloidosis. Also referred to as ‘primary amyloidosis,’ this variation usually affects the heart, kidneys, liver, and nerves.
© Shutterstock
10 / 31 Fotos
Secondary amyloidosis
- Next up is AA amyloidosis, also known as ‘secondary amyloidosis.’ This is usually triggered by an inflammatory disease and primarily affects the kidneys, liver, and spleen.
© Shutterstock
11 / 31 Fotos
Hereditary amyloidosis
- Hereditary amyloidosis, or familial amyloidosis, is an inherited disorder that occurs when a protein made by the liver is abnormal. It mainly affects the nerves, heart, and kidneys.
© Shutterstock
12 / 31 Fotos
Wild-type amyloidosis
- Wild-type amyloidosis occurs when the same liver protein is normal, but it still produces amyloid for unknown reasons. It is most common in men over 70 and tends to affect the heart.
© Shutterstock
13 / 31 Fotos
Localized amyloidosis
- Finally, we have localized amyloidosis, which affects a single site only. Common parts of the body affected by localized amyloidosis include the bladder, skin, throat, and lungs.
© Shutterstock
14 / 31 Fotos
Diagnosing localized amyloidosis
- With localized amyloidosis, it is very important to get the diagnosis right so that general treatments which affect the whole body can be avoided.
© iStock
15 / 31 Fotos
Risk factors
- In terms of risk factors, age and sex are both important. Amyloidosis is normally diagnosed in people between the ages of 60 and 70, and it is more common in men.
© Shutterstock
16 / 31 Fotos
Race
- Race may also play a role: people of African descent appear to be more likely to carry the genetic mutation associated with a type of amyloidosis that harms the heart.
© Shutterstock
17 / 31 Fotos
Kidney dialysis
- In some cases, kidney dialysis can put people at a higher risk of amyloidosis, since it can cause proteins to build up in the blood and eventually be deposited in tissue.
© Shutterstock
18 / 31 Fotos
Kidney dialysis
- However, amyloidosis caused by complications with kidney dialysis is less common nowadays thanks to modern dialysis techniques.
© Shutterstock
19 / 31 Fotos
Diagnosis
- Amyloidosis can be difficult to diagnose because some of the symptoms are very general and can mimic the symptoms of other, more common diseases.
© Shutterstock
20 / 31 Fotos
Early and precise
- That said, early diagnosis is important, since it can help to prevent further organ damage. Precise diagnosis is also important since treatment varies depending on the condition.
© Shutterstock
21 / 31 Fotos
Blood & urine tests
- If your doctor or healthcare professional suspects amyloidosis, they may order blood and/or urine tests to check for an abnormal protein that indicates the disease.
© Shutterstock
22 / 31 Fotos
Tissue samples
- They may also order a tissue sample, otherwise known as a biopsy, to check for signs of amyloidosis.
© Shutterstock
23 / 31 Fotos
Imaging tests
- Imaging tests, such as echocardiograms, MRIs, and nuclear imaging tests can also be used to check the organs for signs of amyloidosis.
© Shutterstock
24 / 31 Fotos
Treatment
- There is no cure for amyloidosis. Instead, treatment focuses on managing the symptoms and limiting any further production of the amyloid protein.
© Shutterstock
25 / 31 Fotos
Chemotherapy
- In the case of AL amyloidosis, chemotherapy is often used to stop the growth of the abnormal cells that produce the protein that produces amyloid.
© Shutterstock
26 / 31 Fotos
Blood thinners
- In cases of amyloidosis that affects the heart, patients may need to take blood thinners to reduce the risk of throwing a blood clot.
© Shutterstock
27 / 31 Fotos
Other medications
- They may also need to take medications to control heart rate, as well as drugs that increase urination, so as to reduce the strain on the heart and kidneys.
© Shutterstock
28 / 31 Fotos
Surgery
- There are also targeted therapies for specific types of amyloidosis, as well as surgical procedures that may be ordered as part of treatment.
© Shutterstock
29 / 31 Fotos
In conclusion
- Living with this rare disease can be difficult, but early diagnosis and the right treatment can help to manage symptoms and prevent complications. Sources: (Mayo Clinic) (NHS) See also: The rare inflammatory condition that is sarcoidosis
© Shutterstock
30 / 31 Fotos
What exactly is amyloidosis?
All about this rare but serious condition
© Shutterstock
When it comes to rare diseases, some get more attention than others. One that tends to slip under the radar is amyloidosis, a disease where the body produces a protein called amyloid, which builds up in the organs and stops them from functioning normally.
There is no cure for this rare condition, but the right treatment can help to ease symptoms and prevent complications.
Curious? Check out this gallery to find out more about amyloidosis.
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